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Sda protein domain
In molecular biology, the protein domain Sda is short for suppressor of dnaA or otherwise known as sporulation inhibitor A. It is found only in bacteria. This protein domain is highly important to cell survival. When starved of nutrients, the cell is under extreme stress so undergoes a series of reactions to increase the chances of survival. One method is to form endospores which can withstand a large amount of environmental pressure. Sda protein domain is a checkpoint which prevents the formation of spores. The Sda domain affects cell signalling. It prevents the cell communicating the stress that it is under, which is crucial if the cell is to survive.
==Cell signalling==
All cells communicate through cell signalling. The Sda protein domain inhibits the Histidine kinase signal transduction. This signal transduction mechanism is switched on when the cell is under stress, such as nutrient deprivation.
It works through the kinase first autophosphorylating the Histidine residue and this triggers sporulation. Sda prevents this pathway from occurring by inhibiting the histidine kinase. More specifically, Sda can be considered an antikinase and binds to KinA. The Sda-KinA complex now physically blocks any phosphorylation of the Histidine Kinase residue.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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